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2013 Innovations in Clinical Research Award

Awarded: Sep 01, 2013

$5.35M over 3 years

In 2013, the foundation awarded three-year grants of $486,000 each to 11 projects that have the potential to catalyze innovative breakthroughs in sickle cell disease. 

2013 ICRA Grantees

Daniel E. Bauer, M.D., Ph.D., and Stuart H Orkin, M.D.
Boston Children’s Hospital and Harvard Medical School
Project name: Genome Editing of the GWAS-Marked BCL11A Enhancer: An Approach to HbF Reactivation in Sickle Cell Disease

Benjamin L. Ebert, M.D., Ph.D., and Maureen M. Okam, M.D., M.P.H.
Brigham and Women's Hospital and Harvard Medical School
Project name: Examination of Human Samples with Somatic Mutations in Hematopoietic Stem Cells to Inform the Biology of Fetal Hemoglobin Induction

Umut A. Gurkan, Ph.D., and Jane A. Little, M.D.
Case Western Reserve University
Project name: "SCD Biochip": Towards a Simple and Reliable Way to Monitor Sickle Cell Disease

Steven J. Hardy, Ph.D., and Kristina K. Hardy, Ph.D.
Children’s National Medical Center
Project name: Feasibility and Efficacy of a Home-Based, Computerized Cognitive Training Program in Pediatric Sickle Cell Disease

Chandy C. John, M.D.
University of Minnesota
Project name: Novel Use Of Hydroxyurea in an African Region with Malaria

Nigel S. Key, M.B., Ch.B., and Kenneth Mann, M.D.
University of North Carolina at Chapel Hill and University of Vermont
Project name: The Effects of Hypoxia on Red Blood Cell-Dependent Thrombin Generation in Sickle Cell Disease

Donald Kohn, M.D.
University of California, Los Angeles
Project name: Site-Specific Gene Modification in Hematopoietic Stem Cells for Sickle Cell Disease

Punam Malik, M.D.
Cincinnati Children's Hospital Medical Center
Project name: Gene Therapy for Sickle Cell Anemia

Leslie V. Parise, Ph.D., and Bruce A. Sullenger, Ph.D.
University of North Carolina at Chapel Hill and Duke University Medical Center
Project name: Targeting Neutrophil Extracellular Traps in Sickle Cell Disease

Rebecca R. Richards-Kortum, Ph.D.
William Marsh Rice University
Project name: Accurate and Inexpensive Point-of-Care Diagnosis of Sickle Cell Anemia

Bamidele Tayo, Ph.D., and Victor R. Gordeuk, M.D.
Loyola University of Chicago and University of Illinois at Chicago
Project name: Risk Stratification for Clinical Severity of Sickle Cell Disease in Nigeria and Assessment of Efficacy and Safety during Treatment with Hydroxyurea